Hope, Sam, Virginia, and Nicole are four women trying to cope with the vicissitudes of life. Struggling to fit her family in with the hectic demands of her career has made Hope feel like a stranger to her husband, Matt, and their two small children. Her unconventional sister Sam has big plans to be the first female music mogul, running her own record label exactly the way she pleases. Virginia and her husband Bill can't wait to build their retirement dream home and spend more time with their granddaughter. Nicole is the wild child, tossing her fate to the winds as she sings and parties her way through life. Now a day of reckoning is coming, as each of them confronts a shattering crisis that will change them in ways they couldn't have predicted. But can they survive the fallout?